课程负责人
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   学术研究
 

科研课题

  毛世瑞教授多年来从事生物可降解高分子材料作为药物载体的研究、鼻黏膜给药系统和纳米药物的研究,注重具有自主知识产权的药物给药系统的研究。近两年来,承担国际合作课题2项,国家级课题3项。
承担的代表性科研项目如下:

1.国家科技部(中泰合作)“聚合物纳米复合物结构特性与大分子药物胃肠吸收”,2009.11-2011.10,项目负责人

2.中美国际合作项目“应用纳米技术提高难溶性药物的生物利用度”, 2009.1-2010.12,项目负责人

3.国家中医药局留学人员科研项目“长效注射PLGA微球的释药特性和影响体内分布的因素”,2008.3-2010.2,项目负责人

4.教育部留学人员科研项目“低分子肝素/壳聚糖及其衍生物的纳米复合物口服吸收的研究”,2008.3-2010.2,项目负责人

5.国家科技部“973”基础研究课题“纳米技术增加难溶药物的水溶性及作用机理研究”,2009.1-2013.12,主要参加人

科研论文

  几年来,共发表国内外科技论文60篇,其中英文24 篇,中文36 篇,SCI收录文章23篇,已被他人引用300次以上,单篇他引的最近统计为77次,另发表会议论文33篇,中英文22 篇,中文11 篇,做英文大会报告 7 次。
近5年来代表性的学术论文如下:

  1. Mao Shirui, Shuai Xintao, Unger Florian, Wittmar Matthias Xiulan Xie and Kissel Thomas. Synthesis, characterization and cytotoxicity of poly (ethylene glycol)-graft-trimethyl chitosan block copolymers, Biomaterials. 2005,26(32),6343-6356. (SCI收录,影响因子6.646)
  2. Mao Shirui, Neu Michael, Germershaus Oliver, Merkel Olivia, Sitterberg Johannes, Bakowsky Udo, and Kissel Thomas. Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene ine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes.Bioconjugate Chem, 2006,17 (5), 1209 -1218. (SCI收录,影响因子4.584)
  3. Mao Shirui, Germershaus Oliver, Fischer Dagmar, Linn Thomas, Schnepf Robert, Kissel Thomas. Uptake and transport of self-assembled PEGylated trimethyl chitosan block copolymer-insulin nanocomplexes in Caco-2 cell monolayers, Pharm Res 2005, 22(12), 2058-2068. (SCI收录,影响因子4.024)
  4. Mao Shirui, Shi Y, Li L, Xu J, Schaper A, Kissel T. Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm. 2008,68,214-223. (SCI收录,影响因子3.344)
  5. Mao Shirui, Xu Jing, Cai Cuifang, Germershaus Oliver, Schaper Andreas, Kissel Thomas. Influence of process parameters on the internal morphology of FITC-dextran loaded PLGA microspheres. Int. J. Pharm.2007,334, 137-148. (SCI收录,影响因子3.061)
  6. Mao Shirui, Bakowsky Udo, Jintapattanakit Anchalee, Kissel Thomas. Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J Pharm Sci ,2006, 95(5), 1036-48. (SCI收录,影响因子2.996)
  7. Mao Shirui, Augsten C, Maeder K, Kissel. T. Characterization of chitosan and its derivatives using asymmetrical flow field-flow-fractionation: A comparison with traditional methods. J Pharm Biomed Anal, 2007, 45(5), 736-41. (SCI收录,影响因子2.629)
  8. Mao Shirui, Shuai Xintao, Unger Florian, Simon Michael, Bi Dianzhou, and Kissel Thomas. The depolymerization of chitosan: Effects on physicochemical and biological properties, Int J Pharm 2004, 281, 45-54. (SCI收录,影响因子3.061)
  9. Mao Shirui, Chen Jianming, Liu Huan, Wei Zhenping, Bi Dianzhou. Intranasal administration of melatonin starch microsphere, Int J Pharm, 2004, 272(1-2), 37-43. (SCI收录,影响因子3.061)
  10. Mao Shirui*, Sun Wei, Kissel T. Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev, 2010,62,12-27. (SCI收录,影响因子8.287)
  11. Mao Shirui, Yang Shiling, Bi Dianzhou. Pharmacodynamics and potential toxicity of intranasally administrated dipyrone. Biol. Pharm. Bull 2006,29(7),1355-9. (SCI收录,影响因子1.765)
  12. Mei Dan, Mao Shirui*, Sun Wei, Thomas Kissel. Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats. Eur J Pharm Biopharm, 2008, 70(3), 874-881. (SCI收录,影响因子3.344)
  13. Sun Wei, Mao Shirui*, Dan Mei and Thomas Kissel. Self-Assembled Polyelectrolyte Nanocomplexes between Chitosan Derivatives and Enoxaparin. Eur J Pharm Biopharm. 2008,69(2),417-425. (SCI收录,影响因子3.344)
  14. Sun Wei, Mao Shirui*, Wang Yanjun, Junyaprasert VB, Zhang Tingting, Na Lidong, Wang Juan. Bioadhesion and oral absorption of enoxaparin nanocomplexes. Int J Pharm 2010,386,275-281. (SCI收录,影响因子3.061)
  15. Zhang Tingting, Mao Shirui*, Sun Wei. Design and in vitro evaluation of a film-controlled dosage form self-converted from monolithic tablet in gastrointestinal environment.Journal of Pharmaceutical Sciences, 2010. (in press) (SCI收录,影响因子2.996)

国际会议大会报告:

1.  Mao Shirui,Kissel T. Polyethylene glycol chain length influences the physicochemical and
biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/siRNA polyplexes. International Conference of The Korean Society of Pharmaceutical Sciences and Technology. November 22-23, 2007, Seoul, Korea.

2.  Mao Shirui. Polymeric nanoparticles as carriers of drug delivery system. APSTJ Global Education Seminar East 2009-03. 2009 Oct 5, Tokyo, Japan.

3.  Wang Yanjun, Mao Shirui*. Effect of particle size on the in vitro-in vivo release of resveratrol from PLGA microspheres. 17th International Symposium on Microencapsulation, 2009 Sep 29-Oct 1, Nagoya, Japan.

4.  Mao Shirui, Sun Wei. Chitosan and its derivatives as the carriers for peroral administration of enoxaparin. Intervarsity Symposium 2008 National University of Singapore (NUS), Shenyang Pharmaceutical University (SPU), Prince of Songkla University (PSU) November 6, 2008. Venue: National University of Singapore.

5.  Mao Shirui, Shi Yi, Li Luk, et al. Effects of process parameters on characteristis and internal morphology of poly(D,L-lactide-co-glycolide) microspheres formed by solvent evaporation method. The first Asian Symposium on Pharmaceutical Sciences and Technology, July 28-30, 2007, Shenyang.

6.  Mao Shirui, Neu Michael, Germershaus Oliver, Merkel Olivia, Sitterberg Johannes, Bakowsky Udo, and Kissel Thomas. Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes. CRS Meeting in Jena, March 2006, Germany.

7.  Mao Shirui, Germershaus Oliver, Fischer Dagmar, Kissel Thomas. Uptake and transport of PEG-graft-trimethyl chitosan block copolymer-insulin nanoparticles in Caco-2 cell monolayers. CRS Meeting in Marburg, March 2005, Germany.

获得奖励

1.获得由国际缓控释协会授予的CRS-Nagai Postdoctoral Research Achievement Award, 2009.
2.Journal of controlled release top ten reviewers (2006,2007,2008)
3.辽宁省百千万人才千人层次, 2009
4.2009年度沈阳药科大学ISP Hulmut Award.
5.辽宁省自然科学学术成果三等奖: Self-assembly polyelectrolyte nanocomplexes between chitosan derivatives and enoxaparin
6.2002-2004年度德意志学术交流中心(DAAD)奖学金
7.日本药学科学技术协会办法的学术报告奖(2009)